Product 11 of 12

Meprate (Medroxyprogesterone Acetate) 10mg, 100tabs, Serum Institute of India

Model Serum Instit
Manufacturer Serum Institute of India
Price:   $76.00

Meprate (Medroxyprogesterone Acetate) 10mg, 100tabs, Serum Institute of India

Manufacturer: Serum Institute of India
Pharmaceutical name: Medroxyprogesterone Acetate
Pack: 5mg, 24tabs
Other Brand Name: Deviry, Meprate, ...

Medroxyprogesterone Acetate is a progestin that helps treat abnormal menstrual periods or irregular vaginal bleeding. It can also help prevent overgrowth of the lining of the uterus and it is included in estrogen replacement therapy to reduce the risk of cancer of the uterus.


Information for patients

Drug Information

Medroxyprogesterone belong to a group of medicines called ‘Progestogens’. Progestogens act like progesterone, a natural sex hormone - Medroxyprogesterone contain the progestogen called medroxyprogesterone acetate. - Medroxyprogesterone acetate can slow down the growth of certain tumours which are sensitive to hormones - Medroxyprogesterone are used in the treatment of cancer in the breast, kidney (in men and women) and in the lining of the womb (endometrial cancer). It is also used to treat cancer which has spread to other parts of the body (metastatic cancer) in post menopausal women (women who have stopped having their periods) - It is not expected that Medroxyprogesterone will be used in children for the above indications. If you are not certain why you are being given this medicine, ask your doctor.


no data available

Before Consuming the Medicine

Avoid Drug

-hypersensitivity (allergy) to Medroxyprogesterone or other similar hormone medicines or any of the other ingredients in Medroxyprogesterone (see Section 6 for further information). - liver problems - A heart condition where you feel pain in your chest when you exert yourself (angina) or have had a heart attack or if you have been told that you are at risk of developing cardiovascular diseases - raised levels of calcium in the blood (hypercalcaemia) in patients with metastasised bone cancer - suspected or recently diagnosed breast cancer for the first time - undiagnosed vaginal bleeding - past or recent blood clot disorders, including deep vein thrombosis (DVT), pulmonary embolitis, thrombophelbitis (inflammation of the blood vessels) or if you have been told that you are at risk of developing these conditions - a history of a condition known as porphyria ( an hereditary blood disorder) - missed abortion (where the woman’s body does not expel the dead foetus), miscarriage or pregnancy

Drug Special Care

- fluid retention - diseases that affect the heart and blood vessels (cardiovascular disease) - epilepsy - migraine headaches - sudden vision disturbance - asthma - liver or kidney problems - diabetes - depression or a history of depression - hyperlipidaemia (raised levels of fat in the blood) - if you are taking or have recently taken any other medicines, even those not prescribed - jaundice (a condition which causes the skin or whites of the eye to appear yellow) - a significant increase in high blood pressure Risk of Venous Thromboembolism (VTE) All women have a small chance of having a blood clot in the veins of the leg, in the lung or other parts of the body. The chances of getting a clot are very slightly increased if you are taking a hormone medicine like Medroxyprogesterone . You are more likely to get a clot whether or not you are taking Medroxyprogesterone if you - are very overweight - have relatives who have had blood clots - have had a blood clot in the veins or lungs before - are unable to move for long periods of time ( for example after an operation) - have a serious injury or have major surgery. - have a history of repeated miscarriage Tell your doctor if you have just had an operation or if you are going to have an operation while taking Medroxyprogesterone . Treatment with Medroxyprogesterone may cause you to have symptoms associated with Cushings Syndrome.

Drug Drug Interactions

- anticonvulsants like phenobarbitol, phenytoin, carbamezapine for epilepsy ( fits) - anti-infective medicines like rifampicin, rifabutin, efavirenz or nevirapine for infections caused by bacteria and yeast - cytotoxics drugs (drugs that kill cancerous cells) - ciclosporin for suppressing the immune system - herbal preparations containing St. John’s Wort - aminogluthemide sometimes used in Cushings syndrome - anticoagulants like warfarin for thinning the blood - Pain killers like aspirin, ibuprofen or naproxen and vasodilators like hydrazalazine, minoxidil may affect the way Medroxyprogesterone work.

Drug Pregnancy Interaction

Avoid becoming pregnant while being treated with Medroxyprogesterone . Medroxyprogesterone must not be taken if you are pregnant as hormonal medicines may affect the developing baby. Tell your doctor if you are pregnant, had an abortion or missed a period during treatment. Your doctor may give you a pregnancy test before starting treatment. If you are sexually active, you are advised to use effective birth control to prevent pregnancy while taking Medroxyprogesterone .

Drug Breast feeding Interaction

You should stop breast feeding before starting treatment with Medroxyprogesterone as this medicine may be harmful to infants being breast-fed. Ask your doctor or pharmacist for advice before taking any medicine while breast feeding.

Drug Machinery Interaction

There are no special precautions, and you can drive or operate machinery as long as you feel well and able to do so.

Drug More Information

no data available

How to take the Medicine

Consumption Info

Please inform your doctor if you need to have any blood tests or gynaecological assessment, as Medroxyprogesterone may affect their results

Drug quanitty

Cancer of the Endometrium (womb lining) and Kidney: The usual dose is 200mg to 600mg a day. Breast Cancer: The usual dose is 400mg to 1500mg a day.

Drug Dose

The chance of having a minor side effect, such as indigestion and weight gain, increase as the dose increases. Swallow each tablet whole. Take your at the same time each day. Follow your doctors instructions. These can be found in the label of your pack. If you are not sure ask your doctor. Treatment may be required for 8 to 10 weeks before any effect can be found.

Excess Drug Consumption

If you take too many Medroxyprogesterone , contact your doctor straight away.

Forgot Drug Consumption

If you forget to take your dose, take the next dose at the usual time. Do not take a double dose to make up for a forgotten dose.

Stop Drug Consumption

Do not stop the drug untill your doctor says you to do so.

Possible Side Effects

General Information

no data available

Common Drug Side Effects

Reasons for seeking immediate medical advice •Rarely, Medroxyprogesterone may cause a severe allergic reaction which can be life-threatening in some cases. If you think you are reacting badly to the medicine get emergency medical help immediately. The symptoms of an allergic reaction could be the following: wheezing, difficulty breathing, feeling faint, swelling of the face or tongue, hands and feet, intense itchy skin rash. •There have also been reported cases of raised blood calcium levels (hypercalcaemia) in patients with breast cancer. Please report any unusual vaginal bleeding, loss of vision or if there is a sudden onset of enlarged eyeball, double vision or migraine. These are symptoms of a blood clot in the lungs which may all occur together: - Sudden, severe, sharp pain in your chest - Coughing up blood - You suddenly become short of breath - Your heart beats more rapidly These can be symptoms of a blood clot in the brain (‘a stroke’) - You have an unusually severe or long headache - Your sight is affected in any way - You find it difficult to speak - You collapse or faint - Any part of your body feels weak or numb or cannot move These are symptoms of a deep-vein thrombosis (DVT). - You have pain, tenderness or swelling in your calf, ankle or foot - You have purple discolouration of the skin of the leg or the skin becomes red and warm to touch Reasons for stopping Medroxyprogesterone immediately Your treatment will be discontinued if you have any of the following symptoms: - yellowing of the skin or whites of the eyes or liver problems - a significant increase in blood pressure - new onset of migraine-type headache

Rare Drug Side Effects

no data available

Very Rare Drug Side Effects

no data available

Drug Side Effects Symptoms

Effects on the reproductive system and breasts: breast pain and tenderness, a milky discharge from the breast when not pregnant or breastfeeding, unexpected or unusual vaginal bleeding or spotting, the stopping or extended break of your periods and vaginal discharge. Effects on your central nervous system: confusion, euphoria (a state of extreme well-being and pleasure), loss of concentration, nervousness, difficulty sleeping, drowsiness, tiredness ,dizziness, depression, vision disorders, and headache. Effects on your digestive system: Constipation, diarrhoea, dry mouth, yellowing of the skin or whites of the eyes, feeling sick and indigestion. Effects on your heart and circulation: blood clots, including clots in the lung, swelling in the veins due to blood clots, stroke, heart attacks, the sensation of feeling your heartbeat and may effect certain blood test (causing raised white blood cells). Effects on your skin, nose, throat or hair: sensitivity reactions ranging from itchy skin, nettle rash or hives, swelling in face/throat which may cause difficulty breathing to a general rash and severe allergic reactions. There have been cases of acne and hair loss or facial hair growth reported. Effect on your metabolism: lack of appetite, feeling thirsty, ,effects like fine hand tremors, sweating, tremors, cramps in calves at night, Cushingoid Syndrome, decreased sugar tolerance, cloudy vision, an increase in your symptoms of diabetes mellitus and may effect both blood and urine tests. When you are being given Medroxyprogesterone , if you feel any change in appetite, change in libido (sex drive), fluid retention, weight gain, tiredness, high fevers, or facial swelling, you must tell your doctor.

How to Store the Medicine

How to Store the Medicine

- The unopened bottles should be stored in the original container until ready for use. - Do not store above 25°C. - Keep out of the reach and sight of children. - Medroxyprogesterone should not be used after the expiry date printed on the box and on the bottle label.

Medroxyprogesterone Uses

Medroxyprogestrone is used in the treatment of abnormal uterine bleeding, endometriosis and amenorrhea. Medroxyprogestrone is also used as a contraceptive or for heavy, painful, irregular or missed periods.

How it Works

Medroxyprogestrone is a progestogen, which is a female hormone. It works as a contraceptive by preventing the ovaries from releasing eggs. Medroxyprogestrone also thickens the cervical mucus and changes the uterine lining, making it harder for sperm to enter or survive in the uterus.

Common Side effects

Patients who take Medroxyprogestrone may suffer from such side effects;

Abdominal pain,
Abdominal distension,
Back pain,
Vaginal discharge,
Decreased libido,
Pain in extremity,
Breast tenderness,
Hair loss