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  • The HGH Fragment is a modified form of amino acids 176-191 of the human Growth Hormone (GH) polypeptide. This peptide, as the name implies, is a piece of the 191 amino chain that makes up growth hormone, from positions 176 through 191 to be exact.
    The HGH Fragment is a modified form of amino acids 176-191 of the human Growth Hormone (GH) polypeptide. This peptide, as the name implies, is a piece of the 191 amino chain that makes up growth hormone, from positions 176 through 191 to be exact.
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HGH Fragment 176-191, 10mg, NouVeaux Ltd

Modell NouVeaux
Hersteller Nouveaux Ltd
Price:   Ƀ42.00000000
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HGH Fragment 176-191, 10mg, NouVeaux Ltd

Products name: HGH Fragment 176-191
Manufacturer: NouVeaux Ltd
Pharmaceutical name: 176-191 growth hormone peptide fragment
Concentration: 10mg
Pack: 1 cartrige (10 mg )

The HGH Fragment is a modified form of amino acids 176-191 of the human Growth Hormone (GH) polypeptide. This peptide, as the name implies, is a piece of the 191 amino chain that makes up growth hormone, from positions 176 through 191 to be exact.

Description

The HGH Fragment is a modified form of amino acids 176-191 of the human Growth Hormone (GH) polypeptide. This peptide, as the name implies, is a piece of the 191 amino chain that makes up growth hormone, from positions 176 through 191 to be exact. This fragment has been shown to induce lipolysis, or fat breakdown, and even inhibits lipogenesis, which is the transformation of food materials into fat stored in the body. Research studies have shown that these happens both to humans and to animals. This short amino-acid chain that make up Fragment 176 is only about 100% of the length of the entire strand of growth hormone and seems to have no other typical positive or negative effects that growth hormone does such as actual growth of tissues or insulin resistance. HGH Fragment (176-191) is a sterile, non-pyrogenic, white lyophilized powder intended for subcutaneous or intramuscular injection, after reconstitution with sterile Water for Injection (0,3% m-Cresol).


Mechanism of action

Investigators and scientists at several studies and researches discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the GH molecule. This region consists of amino acids 176-191, and is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance.

It works by mimicking the way natural GH regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified GH. More specifically, GH cannot be used as an anti-obesity treatment due to adverse effects:

  • Fluid retention
  • Diabetogenic (in high doses)
  • On the contrary, HGH fragment can produce ac inhibition of LPL activity in adipose tissue and stimulate lipolysis in adipocytes. At the same time, HGH fragment appears to have no effect on growth or insulin resistance. In that way treatment with HGH fragment cannot cause diabetogenic problems or influence the insulin metabolism. Also HGH fragment cannot cause fluid retention.

These segments of the synthetic peptides HGH Fragment (176-191) have been investigated for their in vivo effects in laboratory mice musculus. Research results have shown that HGH Frag (176-191) nave resulted to a short-period increase in blood glucose and amore sustained increase in plasma insulin, together with other fragments such as 172-191, 177-191 and 178-191. In addition, the researchers have suggested that functionality of the peptide depends not only in the informational sequence but should also have the correct physical configuration. Also, this fragment, being a region of high accessibility to proteases and also rich in praline, have been demonstrated to affect the conformational change in the cytoplasmic domain of the band 3 of erythrocyte membrane protein by serving as the hinge for the pivoting of the two subdomains. This then suggest that such residue is significant in conformational changes be serving as sites for peripheral protein binding in some body cells.

In another study on animal subjects, they found out that a 500mcg dosage of the said hormone increased the lipolytic activity in adipose tissues without having neg alive influence in the blood glucose level. Futhermore, though it behaves like a human growth hormone (HGH), it does not causes hyperglycemia because it does not compete with HGH receptors. Because of such effects, researchers have suggested that it might be used for the  elimination of excess abdominal fat which is less significant aspect of HIV-associated lipodystrophy. Other studies claimed that protein peptide HGH fragment (176-191) actually acts or the reduction of excessive adipose tissues (body fat) such as those in the abdominal area and increases muscle mass while enhancing the lipid content of the body In laboratory tests on fat cells from humans, HGH fragment released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells and enhanced the burning of fat. HGH fragment reduces body fat in obese subjects and enhanced fat burning without changing food consumption or inducing growth (as it does not increase IGF levels) or any other unwanted GH effect. HGH fragment has no ability to restore the body as HGH, and do not enhances athletic performance. Its entire effectiveness is consist in the extreme mobilization of fat burning.

Other studies claimed that protein peptide HGH fragment (176-191) actually acts or the reduction of excessive adipose tissues (body fat) such as those in the abdominal area and increases muscle mass while enhancing the lipid content of the body. In laboratory tests on fat cells from humans, HGH fragment released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells and enchanced the burning of fat. HGH fragment reduces body fat in obese subjects and enhanced fat burning without changing food consumption or inducing growth (as it dies not increase IGF levels) or any other unwanted GH effect.

So as a conclusion, HGH fragment:

  • Reduces the most stubborn abdominal fat.
  • Increases energy expenditure.
  • Improves lipid profiles and lipolytic activity.
  • Does not negatively impact blood glucose levels.
  • Cell proliferation doesn't occur.
  • Is an extremely potent and effective fat burner.

Adverse reaction

Since only the active fragment of HGH is used, there haven't been observed any of the adverse reactions connected with that hormone.


Instructions for reconstitution

The injection is given into the sub-cutaneous layer which includes adipose tissue (fat).

Hgh fragment 176-191 injection
Hgh fragment 176-191 injection

If you are using insulin syringes which have short needles, you will need to enter the skin at 90°. to the skin, otherwise you can inject as shown in the illustration above with a 29 or 30 gauge, 0.5" needle.

Dosage

Recommended dosage of HGH Fragment (176-191): 500mcg (0.5 mg) once per day.


Storage

  • This product can be used not more than 3 years from the production date (see box).
  • After reconstitution, may be stored for a maximum of 14 days in a refrigerator at 2°C – 8°C.
  • Store vials in an upright position.
  • Store in a refrigerator (2°C – 8°C). Keep in the outer carton in order to protect from light.
  • For one month can be stored at room temperature.



HGH Fragment 176-191, Nouveaux

The 176-191 growth hormone peptide fragment, also known as HGH Frag 176-191, is a modified form of the amino acids 176-191 GH polypeptide. Researchers at Monash University have found that GH's effect on fat reduction appears to be controlled by a small region near one end of the growth hormone molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural growth hormone regulates fat metabolism, but without adversely affecting blood sugar levels or growth that is seen with unmodified growth hormone. Like growth hormone, the hgH 176-191 fragment stimulates lipolysis (breakdown or destruction of fat) and inhibits lipogenesis (conversion of non-fat food materials into fat) in both laboratory and animal studies.


Laboratory tests and HGH fat loss Fragment 176-191

In laboratory tests on fat cells from rodents, pigs, dogs and humans, the hgH fragment released fat specifically from obese fat cells, but not lean cells, reduced the accumulation of new fat in all fat cells, and improved fat burning. In rodents (rats and mice), the hgH fragment reduced adipose tissue in obese animals, but increased fat burning without altering food intake or inducing growth (because it does not increase IGF levels) or any other undesirable effect of growth hormone. Test doses of 500 mcg of the hgH fragment 176–191 daily for 30 days showed a decrease in fat in the middle part of the abdomen in both obese, overweight and moderately built.


Fragment 176-191 as active truncated HGH peptide

The hgH 176-191 fragment is an analogue of growth hormone releasing factor (GRF) that signals growth hormone activity. It is a 15-mer peptide residue of HGH C-terminus to which tyrosine is added at the N-terminus. This synthetically produced hormone is very common among weightlifters and bodybuilders due to a number of physical benefits. Studies have shown that it actually works to reduce excessive amounts of fat, such as those in the abdomen, increase muscle mass and increase lipid content in the body.

These segments of the synthetic hgH 176-191 peptide were tested for their in vivo activity in the muscles of laboratory mice. Study results showed that hgH 176–191 caused a short-term increase in blood glucose and a more sustained increase in plasma insulin levels, along with other fragments, such as 172-191, 177-191 and 178-191. In addition, researchers suggested that the functionality of the peptide not only depends on the information sequence, but should also have the correct physical configuration (Ng and Borstein 1978). It has also been shown that this fragment, which is a region with high availability of proteases and is rich in proline, affects the conformational change in the cytoplasmic domain of the 3 band of erythrocyte membrane protein, serving as a hinge for the rotation of these two subdomains. This then suggests that such a residue is significant in conformational changes, serving as a peripheral protein binding site for certain body cells (Low et al. 1984).

In another study, Ng et al. (2000) in animals, it was found that a dose of 500 μg of this hormone increased lipolytic activity in adipose tissues without adversely affecting blood glucose levels. In addition, although it behaves like human growth hormone (hgH), it does not cause hyperglycemia because it does not compete with hgH receptors (Wu et al. 1993). Because of these effects, the researchers suggested that it could be used to eliminate excess abdominal fat, which is an important aspect of HIV-related lipodystrophy.

(Fragment hgH 176-191) has the ability to burn by stubborn adipose tissue, while increasing energy expenditure, muscle mass and fat oxidation. All studies have shown that this fragment is an effective way to treat obesity and fat loss and much safer than its human growth hormone.